Winger Teddy Thomas replaced the injured Damian Penaud as one of three changes in the side named by France coach Fabien Galthie on Thursday to host Wales this weekend ahead of the end of the Six Nations.
Galthie's men welcome Wayne Pivac's team to Paris on Saturday in a Test match, a week before a potential tournament decider against Ireland which was rescheduled due to the coronavirus pandemic.
Les Bleus' players will only be allowed to play a maximum of three matches each during the six-game campaign after the French Rugby Federation and the French league came to an agreement last week over player availability away from club duty.
Penaud is suffering from an ankle problem, Vincent Rattez comes in for Arthur Vincent as Gael Fickou reverts to centre and Jean-Baptiste Gros takes the place of the retired Jefferson Poirot at loosehead prop from the loss at Scotland in March.
Tighthead Mohamed Haouas keeps his place after serving his suspension for punching Jamie Ritchie at Murrayfield.
France will face Fiji, Italy and Scotland in a newly-created Autumn Nations Cup in November which has replaced the international matches originally scheduled for next month.
Kick-off is at 17:10 (SA time) on Saturday.
15 Anthony Bouthier, 14 Teddy Thomas, 13 Virimi Vakatawa, 12 Gael Fickou, 11 Vincent Rattez, 10 Romain Ntamack, 9 Antoine Dupont, 8 Gregory Alldritt, 7 Charles Ollivon (captain), 6 Francois Cros, 5 Paul Willemse, 4 Bernard Le Roux, 3 Mohamed Haouas, 2 Julien Marchand, 1 Cyril Baille
Substitutes: 16 Camille Chat, 17 Jean-Baptiste Gros, 18 Demba Bamba, 19 Romain Taofifenua, 20 Dylan Cretin, 21 Baptiste Serin, 22 Thomas Ramos, 23 Arthur Vincent